Background:

This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis.

Applications:

WB

Name of antibody:

RET(Phospho-Tyr905)

Immunogen:

Synthetic peptide of human RET

Full name:

ret proto-oncogene

Synonyms:

PTC; MTC1; HSCR1; MEN2A; MEN2B; CDHF12; CDHR16; RET-ELE1

SwissProt:

P07949

WB Predicted band size:

124 kDa

WB Positive control:

COS7 whole cell lysates

WB Recommended dilution:

500-1000