Background:

This gene encodes the large subunit of replication factor C, a five subunit DNA polymerase accessory protein, which is a DNA-dependent ATPase required for eukaryotic DNA replication and repair. The large subunit acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It may also have a role in telomere stability. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Applications:

WB

Name of antibody:

RFC1

Immunogen:

Fusion protein of human RFC1

Full name:

replication factor C (activator 1) 1, 145kDa

Synonyms：

A1; MGC51786; MHCBFB; PO-GA; RECC1; RFC; RFC140

SwissProt:

P35251

WB Predicted band size:

128 kDa

WB Positive control:

MCF7 cells

WB Recommended dilution:

500-2000