IHC Recommend dilution:

25-100

IHC positive control:

Human liver cancer

ELISA Recommended dilution:

2000-5000

SwissProt:

Q8WZ73

Synonyms：

CARP2; FRING; CARP-2; RNF189; RNF34L; RIFIFYLIN

Full name:

ring finger and FYVE-like domain containing E3 ubiquitin protein ligase

Immunogen:

Fusion protein of human RFFL

Name of antibody:

RFFL

Applications:

ELISA, IHC

Background:

E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Also ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate apoptosis downstream of death domain receptors. Also negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation.