Background:

This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death.

Applications:

ELISA, IHC

Name of antibody:

TMEM123

Immunogen:

Fusion protein of human TMEM123

Full name:

transmembrane protein 123

Synonyms：

KCT3; PORMIN; PORIMIN

SwissProt:

Q8N131

ELISA Recommended dilution:

2000-10000

IHC positive control:

Human liver cancer

IHC Recommend dilution:

30-150