Background:

TMPRSS11F is a type-II transmembrane protease, similar to hepsin (TMPRSS1). TMPRSS11F is a member of a larger family of membrane attached serine proteases, a poorly defined group that includes TMPRSS11A, B, C, D, E, F, Hepsin, Corin, Matriptase-1, 2 and 3. TMPRSS11F has a domain structure of an aminoterminal cytoplasmic domain, followed by a transmembrane domain, a SEA domain (Sea urchin sperm protein, Enterokinase, Agrin), a short spacer, then the trypsin-like serine protease domain. The SEA domain is thought to play a role in carbohydrate binding in the analogous protein sequences where it is found, but its role in TMPRSS11F is unclear. The cleavage of the Arg206-Ile207 bond is thought to liberate the catalytic domain.

Applications:

ELISA, WB

Name of antibody:

TMPRSS11F

Immunogen:

Synthetic peptide of human TMPRSS11F

Full name:

transmembrane protease, serine 11F

SwissProt:

Q6ZWK6

ELISA Recommended dilution:

1000-2000

WB Predicted band size:

49 kDa

WB Positive control:

Human esophagus and thyroid cancer tissue

WB Recommended dilution:

200-1000