Background:

This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene.

Applications:

ELISA, IHC

Name of antibody:

TNFAIP3

Immunogen:

Fusion protein of human TNFAIP3

Full name:

TNF alpha induced protein 3

Synonyms:

A20; AISBL; OTUD7C; TNFA1P2

SwissProt:

P21580

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human esophagus cancer

IHC Recommend dilution:

200-400