Background:

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.

Applications:

ELISA, WB, IHC

Name of antibody:

TNFRSF1B

Immunogen:

Fusion protein of human TNFRSF1B

Full name:

Tumor necrosis factor receptor superfamily, member 1B

Synonyms：

p75; TBPII; TNFBR; TNFR2; CD120b; TNFR1B; TNFR80; TNF-R75; p75TNFR; TNF-R-II

SwissProt:

P20333

ELISA Recommended dilution:

1000-2000

IHC positive control:

Human liver cancer and human cervical cancer

IHC Recommend dilution:

5-20

WB Predicted band size:

48 kDa

WB Positive control:

Human colon cancer

WB Recommended dilution:

200-1000