Background:

The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene.

Applications:

ELISA, WB

Name of antibody:

TNFRSF10B

Immunogen:

Synthetic peptide of human TNFRSF10B

Full name:

TNF receptor superfamily member 10b

Synonyms:

DR5; CD262; KILLER; TRICK2; TRICKB; ZTNFR9; TRAILR2; TRICK2A; TRICK2B; TRAIL-R2; KILLER/DR5

SwissProt:

O14763

ELISA Recommended dilution:

5000-10000

WB Predicted band size:

48 kDa

WB Positive control:

PC-3 cell lysate

WB Recommended dilution:

1000-5000