Background:

TNIK (TRAF2 and NCK-interacting protein kinase) is a 1,360 amino acid protein that contains one protein kinase domain and belongs to a subfamily of Ser/Thr protein kinases. Expressed ubiquitously with highest expression in brain, heart and skeletal muscle, TNIK functions as a stress-activated Ser/Thr kinase that catalyzes the ATP-dependent phosphorylation of target proteins and is thought to play a role in the response to environmental stress. Additionally, via its catalytic activity, TNIK may participate in cytoskeletal regulation events throughout the cell. TNIK exists as 8 isoforms that are produced by alternative splicing events.

Applications:

ELISA, IHC

Name of antibody:

TNIK

Immunogen:

Synthetic peptide of human TNIK

Full name:

TRAF2 and NCK interacting kinase

SwissProt:

Q9UKE5

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human brain and human liver cancer

IHC Recommend dilution:

25-100