Background:

This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway.

Applications:

WB

Name of antibody:

TNK2(Ab-284)

Immunogen:

Synthesized peptide derived from Internal of human ACK1.

Full name:

tyrosine kinase, non-receptor, 2

Synonyms：

ACK; ACK1; ACK-1; p21cdc42Hs

SwissProt:

Q07912

WB Predicted band size:

115 kDa

WB Positive control:

293 cells and K562 cells lysates

WB Recommended dilution:

500-3000