Background:

This gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Applications:

ELISA, IHC

Name of antibody:

TOP1MT

Immunogen:

Synthetic peptide of human TOP1MT

Full name:

topoisomerase (DNA) I, mitochondrial

SwissProt:

Q969P6

IHC positive control:

Human gastric cancer and human lung cancer

IHC Recommend dilution:

42510