Background:

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA.

Applications:

ELISA, WB

Name of antibody:

TOP2B

Immunogen:

Synthetic peptide of human TOP2B

Full name:

topoisomerase (DNA) II beta 180kDa

Synonyms：

TOPIIB; top2beta

SwissProt:

Q02880

ELISA Recommended dilution:

2000-5000

WB Predicted band size:

183 kDa

WB Positive control:

Raw264.7, Jurkat, K562 and hepg2 cells

WB Recommended dilution:

500-2000