Background:

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability.

Applications:

WB

Name of antibody:

TOP3B

Immunogen:

Synthesized peptide derived from internal of human TOP3B.

Full name:

topoisomerase (DNA) III beta

Synonyms：

TOP3B1

SwissProt:

O95985

WB Predicted band size:

97 kDa

WB Positive control:

HepG2 cells, COLO205 cells and Huvec cells lysates

WB Recommended dilution:

500-3000