Background:

The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway.

Applications:

WB, IHC

Name of antibody:

TRADD

Immunogen:

Synthesized peptide derived from Internal of human TRADD.

Full name:

TNFRSF1A-associated via death domain

Synonyms：

Hs.89862

SwissProt:

Q15628

IHC positive control:

Human breast carcinoma tissue

IHC Recommend dilution:

50-100

WB Predicted band size:

34 kDa

WB Positive control:

COS7 cells lysate

WB Recommended dilution:

500-3000