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  • 產品名稱:CCM2 抗原(重組蛋白)

  • 產品型號:1mg
  • 產品廠商:通蔚生物
  • 產品價格:3580
  • 產品庫存:35
  • 產品文檔:
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詳情介紹:

中文名稱: CCM2 抗原(重組蛋白)

英文名稱: CCM2 Antigen (Recombinant Protein)

別      名: CCM2 scaffolding protein; OSM; C7orf22; PP10187

儲      存: 冷凍(-20℃)

相關類別: 抗原

概     述

Fusion protein corresponding to a region derived from 245-444 amino acids of human CCM2

技術規格

Full name:

CCM2 scaffolding protein

Synonyms:

OSM; C7orf22; PP10187

Swissprot:

Q9BSQ5

Gene Accession:

BC004903

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.





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