Background:

This gene encodes an enzyme belonging to the glycosyl hydrolase 47 family. This enzyme functions in N-glycan biosynthesis, and is a class I alpha-1,2-mannosidase that specifically converts Man9GlcNAc to Man8GlcNAc isomer B. It is required for N-glycan trimming to Man5-6GlcNAc2 in the endoplasmic-reticulum-associated degradation pathway. Mutations in this gene cause autosomal-recessive intellectual disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 11.

Applications:

ELISA, IHC

Name of antibody:

MAN1B1

Immunogen:

Fusion protein of human MAN1B1

Full name:

mannosidase alpha class 1B member 1

Synonyms:

MRT15; ERMAN1; ERManI; MANA-ER

SwissProt:

Q9UKM7

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human prostate cancer

IHC Recommend dilution:

50-200