Background:

This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver.

Applications:

WB

Name of antibody:

MAP2K4

Immunogen:

Synthetic peptide of human MAP2K4

Full name:

mitogen-activated protein kinase kinase 4

Synonyms：

JNKK; MEK4; MKK4; SEK1; JNKK1; SERK1; MAPKK4; PRKMK4; SAPKK1; SAPKK-1

SwissProt:

P45985

WB Predicted band size:

44 kDa

WB Positive control:

HUVEC cells

WB Recommended dilution:

500-1000