Background:

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.

Applications:

ELISA, WB, IHC

Name of antibody:

MAPK9

Immunogen:

Synthetic peptide of humanMAPK9

Full name:

mitogen-activated protein kinase 9

Synonyms：

JNK2, SAPK, p54a, JNK2A, JNK2B, PRKM9, JNK-55, SAPK1a, JNK2BETA, p54aSAPK, JNK2ALPHA

SwissProt:

P45984

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human esophagus cancer and Human lung cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

48 kDa

WB Positive control:

Raw264.7 cells, Mouse brain and heart tissue

WB Recommended dilution:

500-2000