Background:

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Applications:

ELISA, WB, IHC

Name of antibody:

MAPK10

Immunogen:

Synthetic peptide of human MAPK10

Full name:

mitogen-activated protein kinase 10

Synonyms：

JNK3, JNK3A, PRKM10, SAPK1b, p493F12, p54bSAPK

SwissProt:

P53779

ELISA Recommended dilution:

1000-5000

IHC positive control:

Human breast cancer

IHC Recommend dilution:

5-20

WB Predicted band size:

53 kDa

WB Positive control:

293T cells

WB Recommended dilution:

500-2000