Background:

MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to regulate early endosome-to-trans-Golgi network (TGN) trafficking (Bartee et al., 2004 [PubMed 14722266]; Nakamura et al., 2005 [PubMed 15689499]).[supplied by OMIM, Mar 2010]

Applications:

ELISA, WB

Name of antibody:

MARCHF2

Immunogen:

Fusion protein of human MARCHF2

Full name:

membrane associated ring-CH-type finger 2

Synonyms:

MARCH2; RNF172; HSPC240; MARCH-II

SwissProt:

Q9P0N8

WB Predicted band size:

27 kDa

WB Positive control:

Human fetal liver tissue

WB Recommended dilution:

200-1000