Background:

MARVELD1 (MARVEL domain containing 1), also known as GB14, MARVD1 or MRVLDC1, is a 173 amino acid protein that is widely expressed and contains one MARVEL (MAL and related proteins for vesicle trafficking and membrane link) domain. The MARVEL domain, which is common in Occludin proteins, is a 130 amino acid motif that contains four transmembrane helices, both of which have cytoplasmic N- and C-terminal regions. Localizing to the nucleus, MARVELD1 is downregulated in primary multiple tumors of liver, bladder, ovary, vulva, breast, testis, uterus, kidney and testis. The gene encoding MARVELD1 maps to human chromosome 10, which makes up approximately 4.5% of total DNA in cells and encodes nearly 1,200 genes. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman’s syndrome and Cowden syndrome.

Applications:

ELISA, WB, IHC

Name of antibody:

MARVELD1

Immunogen:

Synthetic peptide of human MARVELD1

Full name:

MARVEL domain containing 1

Synonyms：

GB14; MARVD1; MRVLDC1; bA548K23.8

SwissProt:

Q9BSK0

ELISA Recommended dilution:

1000-2000

IHC positive control:

Human cervical cancer and Human colon cancer

IHC Recommend dilution:

50-200

WB Predicted band size:

19 kDa

WB Positive control:

Mouse heart tissue

WB Recommended dilution:

200-1000