Full name:

laminin, alpha 1

Synonyms:

LAMA, S-LAM-alpha

Gene Accession:

NP_005550

SwissProt:

P25391

Background:

Laminin subunit alpha-1 is a protein that in humans is encoded by the LAMA1 gene. Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-1 is a subunit of laminin-1 (laminin-111 or EHS laminin) and laminin-3 (laminin-121 or S-laminin). Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.